Modelling the controls of the eukaryotic cell cycle.

نویسندگان

  • B Novák
  • J J Tyson
چکیده

The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 31 Pt 6  شماره 

صفحات  -

تاریخ انتشار 2003